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PMID: 20959578 ã¢ã¬ã³ããã³é žã»ãªã»ããã³é žã»ããã¹ããã§ããïŒéªšç²é¬çã®äºé²ãšæ²»çã¬ã€ãã©ã€ã³2015幎çã«ããïŒ (12) Compston J, et al. 2003. âãã¿ãã³D3 2011 May 3;2011. pii: 1109. 骚ç²é¬çæ²»çå€ïŒããåæRANKLã¢ãã¯ããŒãã«æäœè£œå€ïŒæã©ã³ã¯ã«æäœè¬ åºæ¥ãéãæ£ç¢ºãªæ å ±ããäŒãã§ããããã«å¿ãããŠããŸãããå å®¹ã®æ£ç¢ºæ§ã«ã€ããŸããŠã¯äžåä¿èšŒãããã®ã§ã¯ãããŸãããå¿ ãæ·»ä»ææžãè©²åœæç®ããåç §ãã ãããæäŸããŠããèšäºã®å 容ãããããªãæå€±ãæå®³ãªã©ã®è¢«å®³ãçºçãããšããŠããåœãµã€ãã§ã¯è²¬ä»»ãè² ããããŸãã. (6) Valimaki MJ, et al. (5) Curhan GC, et al. BMJ. Rp.1ïŒãžã£ããã¢50mgã1é å1ãæé£åŸããããã30æ¥åRp.2ïŒã¢ãžã¬ã¯ã1mgã1é å1ãæé£åŸããããã30æ¥åRp.3ïŒã¢ããã£ãŒã¶24ÎŒgã2capå2ãæå€é£åŸãããã30æ¥å, 骚åžåæå¶ããã¹ãã¹ãããŒãç³»ãSERMïŒSelective Estrogen Receptor ModulatorïŒéžæçãšã¹ããã²ã³å容äœã¢ãžã¥ã¬ãŒã¿ãŒïŒãä»åã¯å ¥ããŠãªãããã©ãªã¢ïŒããã¹ããïŒã®æRANKLæäœã女æ§ãã«ã¢ã³å€ã, ãã¹ãã¹ãããŒãç³»ã¯ç Žéªšçްèã«åã蟌ãŸããããšã«ããã¢ãããŒã·ã¹ãèªå°ããŠç Žéªšçްèã®äœçšãæå¶ããã, SERMã¯ãšã¹ããã²ã³å容äœã«çµåãã骚åžåãæå¶ã®ãšã¹ããã²ã³æ§äœçšãçºæ®ãããä¹³æ¿ãåå®®ã«å¯ŸããŠã¯äœçšããªãã, 女æ§ãã«ã¢ã³å€ã¯äžè¶³ãã女æ§ãã«ã¢ã³ãè£ãããšã§ç Žéªšçްèã®åããæå¶ããããšã§éªšæžå°ãé²ãã, å¯ç²ç¶è ºãã«ã¢ã³å€ã¯äžææçã«å¯ç²ç¶è ºãã«ã¢ã³ã®æ¿åºŠãé«ããããšã«ããã骚èœçްèãå¢å ãã骚圢æãä¿é²ãããã, ãã¿ãã³D3補å€ã¯è žã§ã«ã«ã·ãŠã ã®åžåãé«ããããã¿ãã³K2補å€ã¯ã«ã«ã·ãŠã ã®éªšãžã®æ²çãä¿é²ãããã«ã«ã·ãŠã 補å€ã¯éªšã®ææã«ãªãããšã«ãã£ãŠã骚代è¬ãæ¹åããã, ãã¹ãã¹ãããŒãã¯ãšããã³ã¹ãå€ããçŸåšç¬¬äžéžæã«ãªãããæ°å¹Žäœ¿çšããã骚質ã®å£åãªã©ã®åé¡ããããããäžæŠè©äŸ¡ãå¿ èŠã, SERMã¯ãã¹ãã¹ãããŒãã»ã©ã¯ã£ãã广ããªããã軜床ããäžç床ã§ããã°çšæ³ãç°¡åãªã®ã§äœ¿ããããã, ãã¹ãã¹ãããŒããšSERMã¯ããŸã䜵çšäŸãèŠãªããçŠå¿ãäœµçšæ³šæã«èšå®ã¯ãªããçŠå²¡çè¬å€åž«äŒã®ãµã€ãã§ã¯ãåç¬çæ³ãã骚å¯åºŠãäžæããå ±åãããããããã骚ææå¶å¹æã«ã€ããŠã¯æ€èšŒãããŠããããå®å šæ§ã®æ€èšãååã§ã¯ãªãããšã®ããšã, 女æ§ãã«ã¢ã³å€ã¯æŽåœ¢ã®å»åž«ã¯ããŸã䜿ããªãå°è±¡ã婊人ç§ç³»ã§ä»ã®çŸæ£ãå«ããŠåŠæ¹ãããã±ãŒã¹ãèŠããSERMãšéã£ãŠã骚以å€ã®å容äœã§ãä¿é²äœçšããããããé·æäœ¿çšã¯ãªã¹ã¯ãå€ãããã ããšã¹ãã©ãŒãã®ããŒãå€ã¯ä»ã«ã¯ãªãå€åã§ããã人ã«ãã£ãŠã¯äœ¿ããããã¡ãªããã¯ããã, éªšä»£è¬æ¹åã¯ãã¿ãã³D3ãã¡ã€ã³ã§äœ¿ããããæ€æ»å€çã«å¿ããŠã«ã«ã·ãŠã 補å€ããã¿ãã³K2補å€ãéžæãããã, ãã¹ãã¹ãããŒãã®äžã®äœ¿ãåãã¯ãåŠæ¹å»ã®å¥œã¿ã«ãããšããã倧ããããæ¯æ¥æäžãé±1æäžãæ1æäžã¯ãã¡ããæ£è ã®èŠæã«ãã£ãŠã䜿ãåããã, 第äºäžä»£ã®ã¢ã¬ã³ããã³ïŒãã©ãµããã¯ããããã³ïŒã¯ãšããã³ã¹ãè±å¯ã飿¥ã®5mgãšé±1ã®35mgããŒãªãŒããããã€ãã³ããã³é žïŒãã³ããïŒãåé¡äžã¯ç¬¬äºäžä»£ïŒå€æ¥ã ãšæäžåã®100mgãããã, 第äžäžä»£ã¯ãã匷åãªéªšåžåæå¶ãšèšãããŠããããªã»ããã³ïŒã¢ã¯ããã«ãããããïŒã¯é£æ¥ã®2.5mgãé±1ã®17.5mgãæ1ã®75mgãšçš®é¡ãå€ããããããã³ïŒããããªããªã«ã«ãã³ïŒã¯1mgã®é£æ¥ãšã50mgã®4é±ã«1åã®èŠæ Œãããã, ãã¿ãã³D3補å€ã¯ã¬ã€ãã©ã€ã³ã ãšãšã«ãã«ã«ã·ããŒã«ïŒãšãã£ããŒã«ïŒãæšå¥šåºŠãé«ãããã ãã¢ã«ãã¡ã«ã«ã·ããŒã«ãæãã䜿çšã®æ£è ããã§åŠæ¹ãå€ãã, ä»åã®èšäºã®ãããªãè¬å€åž«ã®å°éæ å ±ã¯ãããæ€çŽ¢ã§ããªããªãèŠã€ãããªãã£ããããŸãã, ç¡æã§äœ¿ãã倧æã®è¬å€åž«ããŒã¿ã«ãµã€ãã ãšm3.comãšæ¥çµDIã®2çš®é¡ãæåã©ããã§ããã, m3.comã¯æ¥çãã¥ãŒã¹ã®ä»ã«ããè¬å€åž«æ²ç€ºæ¿ã®æ©èœããããéåžžã®ãããæ€çŽ¢ã§ã¯èŠã€ãããªããããªæ å ±ãä»ã®è¬å€åž«ã®èããªã©ãç¥ãããšãã§ããŸãã, é²èЧã ãã§ãå匷ã«ãªããŸããããã¡ããèªåã§è³ªåãããŠåçããããããšãã§ããŸãã, æ¥çµDIãæ¥çãã¥ãŒã¹ãèªã¿ããã圢ã§é ä¿¡ãããŠããŸãããã¡ãã¯è¬å€åž«æ²ç€ºæ¿ã®æ©èœã¯ãããŸããããåŠæ¹è¬èŸå žãªã©äœ¿ããããã³ã³ãã³ãããããŸãã, ã¡ãªã¿ã«ç»é²å®äºãŸã§ã¯ã1ã2åãããã®ã§ãæ£çŽå°ãé¢åãããã§ããå€åå ãšããå ¥åããå¿ èŠãããã®ã§ã, ããããä»ãããªããšåŸã§ã¯ãã£ãšããæ°ã«ãªããªãã®ã§ãã¡ãªãããæããå Žåã¯ä»ãç»é²ããŠãè¯ãã§ãããã, ãã¡ãªãããšããŠã¯ããã¥ãŒã¹ã¡ãŒã«ãšããæ¥ãããã«ãªããŸããç»é²ããã¡ãŒã«ã¢ãã¬ã¹ã¯ã泚æãã ããã, å€åå æ å ±ãç»é²ããŸãããå€åå ã«é»è©±ãšããããã£ãŠããããæ¬äººç¢ºèªãæ¥ãããšã¯ãªãã§ãã®ç¹ã¯å®å¿ããŠãã ããã, 次åã®ã³ã¡ã³ãã§äœ¿çšãããããã©ãŠã¶ãŒã«èªåã®ååãã¡ãŒã«ã¢ãã¬ã¹ããµã€ããä¿åããã, è¬å€åž«ãä»ããå ã«é²ãããããªæ å ±ããçµéšãšå®äœéšã«åºã¥ããå人çèŠè§£ã亀ããŠãäŒãããŸãã. (9) Chlebowski RT, et al. ãã¹ãã¹ãããŒãè£œå€ ããªãã©ããé ¢é žå¡©ïŒããªãã³ïŒ1é±éã«1å æ³šå°ããã. JAMA. 骚ç²é¬çã®æ²»çè¬ ããªãã³æ³šå°ã¯ç§ã«ã¯å¯äœçšã匷ã諊ããããåŸãªãã£ã; 骚ç²é¬çæ²»çè¬ããªãã³æ³šå°ãæ¢ããŠããªã«ã«ãã³é 50ãã6ã«æé£²ã¿ç¶ããçµæéªšå¯åºŠãäžæ; 骚ç²é¬çæ²»çè¬ãã©ãªã¢æ³šå°ãšããã¿ã¹ãã¥ã¢ãã«é åé ã®æ²»ç ãããã¢ã³ããã¯ã骚ãäžå€«ã«ãã骚ç²é¬çã®æ²»çè¬ã§ãã PMID: 8069139 äž»ã«æµ·ç¶¿éªšã匷ãããŸãã (7) Rossouw JE, et al. 1994 Jul 23;309(6949):230-5. 骚ç²é¬çã«ãã骚æã¯è骚ãæéŠãèãè ã®ä»ãæ ¹ã«èµ·ã... è¬å€åž«ã§ãã ïŒå¶éãèšããããŠããã®ã¯ã PMID: 7121250. Am J Med. PMID: 18319414 JAMA. ã€ãŸãã骚æã®å¯èœæ§ãçžå¯Ÿçã«38.1ïŒ æžããŸããã, æ¥æ¬ã§ã¯2016幎ïŒïŒæã«çºå£²ãããããæ¬§ç±³ã§ã¯å¹ŽïŒåæäžè£œå€ãšããŠïŒïŒïŒïŒå¹Žã«æ¿èªãåããŠãããæ¬§ç±³ã§ã®ããŒã¿ãè±å¯ã§ããã JAMA. 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